Mouse Monoclonal Antibody to WAS | ProMab 30716 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to WAS

catalog :

30716

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B10E4

The same clone is also sold as:

Invitrogen: MA5-31952
Novus Biologicals: NBP2-52587
Abcam: ab202025

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30716

Title :

Mouse Monoclonal Antibody to WAS

Species :

Human;

Clone :

7B10E4;

lsotype :

Mouse IgG2a

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Immunogen :

Purified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Mol Cell Biol. 2012 Aug;32(15):3153-63.; 2. Dis Markers. 2010;29(3-4):157-75.

Type :

Monoclonal Antibody

MW :

53kDa

Aliases :

THC; IMD2; SCNX; THC1; WASP