Mouse Monoclonal Antibody to TCL1A | ProMab 30715 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to TCL1A

catalog :

30715

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2E3A5

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30715

Title :

Mouse Monoclonal Antibody to TCL1A

Species :

Human;

Clone :

2E3A5;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).

Immunogen :

Purified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

References :

1. Blood. 2012 Aug 23;120(8):1613-23.; 2. Histopathology. 2010 Jul;57(1):152-7.

Type :

Monoclonal Antibody

MW :

13.5kDa

Aliases :

TCL1