antibody

Mouse Monoclonal Antibody to WT1

30712

0.1 mg

monoclonal

mouse

nonconjugated

5G11A5

The same clone is also sold as:

• Abcam: ab201948

western blot, ELISA, flow cytometry

Mouse Monoclonal Antibody to WT1

Human;

5G11A5;

IgG1

0.1 mg

4℃; -20℃ for long term storage

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Purified recombinant fragment of human WT1 (AA: 314-479) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

1. Leuk Res. 2013 Oct;37(10):1341-9. ; 2. Pediatr Blood Cancer. 2013 Aug;60(8):1388-9.

Monoclonal Antibody

49.2kDa

GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1