Mouse Monoclonal Antibody to APP | ProMab 30709 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to APP

catalog :

30709

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H10A10

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30709

Title :

Mouse Monoclonal Antibody to APP

Species :

Human;

Clone :

5H10A10;

lsotype :

Mouse IgG2b

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Immunogen :

Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

References :

1. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14604-9.; 2. ACS Chem Neurosci. 2013 Mar 20;4(3):454-62.

Type :

Monoclonal Antibody

MW :

87kDa

Aliases :

AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma