Mouse Monoclonal Antibody to ABCB1 | ProMab 30593 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ABCB1

catalog :

30593

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6G11F8

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30593

Title :

Mouse Monoclonal Antibody to ABCB1

Species :

Human;

Clone :

6G11F8;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ;

Immunogen :

Purified recombinant fragment of human ABCB1 (AA: 632-693) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Pharmacol Rep. 2012;64(6):1560-6. ; 2. J Cancer Res Ther. 2012 Apr-Jun;8(2):226-31. ;

Type :

Monoclonal Antibody

MW :

141.5kDa

Aliases :

CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170