Mouse Monoclonal Antibody to PTPRC | ProMab 30586 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PTPRC

catalog :

30586

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C10C11

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

30586

Title :

Mouse Monoclonal Antibody to PTPRC

Species :

Human;

Clone :

2C10C11;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. ; ;

Immunogen :

Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Biochem Biophys Res Commun. 2012 Mar 23;419(4):708-14. ; 2. Blood. 2009 Jun 4;113(23):5905-10. ;

Type :

Monoclonal Antibody

MW :

147.3kDa

Aliases :

LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180