Mouse Monoclonal Antibody to TFRC | ProMab 30561 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to TFRC

catalog :

30561

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A1B2

The same clone is also sold as:

Novus Biologicals: NBP2-37317

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

Catalog :

30561

Title :

Mouse Monoclonal Antibody to TFRC

Species :

Human; Mouse; Monkey; Rat;

Clone :

1A1B2;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses. ; ;

Immunogen :

Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Folia Histochem Cytobiol. 2012 Jul 5;50(2):304-11. ; 2. J Biol Chem. 2011 Oct 14;286(41):35708-15. ;

Type :

Monoclonal Antibody

MW :

85kDa

Aliases :

T9; TR; TFR; p90; CD71; TFR1; TRFR