antibody

Mouse Monoclonal Antibody to BRCA1

30509

0.1 mg

monoclonal

mouse

nonconjugated

6C6D2

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to BRCA1

Human;

6C6D2;

Mouse IgG1

0.1 mg

4℃; -20℃ for long term storage

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. ; ; ;

Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1. Cancer Res. 2013 Jan 15;73(2):706-15. ; 2. J Biol Chem. 2012 Nov 23;287(48):40618-28. ;

Monoclonal Antibody

207.7kDa

IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53