Mouse Monoclonal Antibody to FLT3 | ProMab 30507 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to FLT3

catalog :

30507

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B7C3

The same clone is also sold as:

MyBioSource: MBS476418
Invitrogen: MA5-38523
Novus Biologicals: NBP2-37363

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

30507

Title :

Mouse Monoclonal Antibody to FLT3

Species :

Human;

Clone :

7B7C3;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. ;

Immunogen :

Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. J Immunol. 2012 Oct 15;189(8):3822-30. ; 2. Cancer. 2012 Dec 15;118(24):6110-7. ;

Type :

Monoclonal Antibody

MW :

130kDa

Aliases :

FLK2; STK1; CD135; FLK-2