Mouse Monoclonal Antibody to CD33 | ProMab 30480P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CD33

catalog :

30480P

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C6B7

The same clone is also sold as:

Novus Biologicals: NBP2-37388

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30480P

Title :

Mouse Monoclonal Antibody to CD33

Species :

Human;

Clone :

2C6B7;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

Immunogen :

Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. MAbs. 2011 Jan-Feb;3(1):21-30. ; 2. Hum Genet. 2012 Jul;131(7):1245-9.

Type :

Monoclonal Antibody

MW :

39.8kDa

Aliases :

p67; SIGLEC3; SIGLEC-3