Mouse Monoclonal Antibody to C17ORF53 | ProMab 30461P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to C17ORF53

catalog :

30461P

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7A3A9

The same clone is also sold as:

Novus Biologicals: NBP2-37407
Invitrogen: MA5-17037

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, flow cytometry

product information

Catalog :

30461P

Title :

Mouse Monoclonal Antibody to C17ORF53

Species :

Human;

Clone :

7A3A9;

lsotype :

Mouse IgG2b

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. ; ; ;

Immunogen :

Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/50; FCM: 1/200 - 1/400

References :

1.Nat Genet. 2009 Jan;41(1):15-7. ;

Type :

Monoclonal Antibody

MW :

69.8kDa