Mouse Monoclonal Antibody to CDKN2A | ProMab 30434 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CDKN2A

catalog :

30434

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D7D2

The same clone is also sold as:

Invitrogen: MA5-17054

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30434

Title :

Mouse Monoclonal Antibody to CDKN2A

Species :

Human;

Clone :

1D7D2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. ; ; ; ; ;

Immunogen :

Purified recombinant fragment of human CDKN2A (AA: 1-156) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.Clin Cancer Res. 2011 Dec 1;17(23):7413-23. ; 2.Appl Immunohistochem Mol Morphol. 2011 Dec;19(6):562-8. ;

Type :

Monoclonal Antibody

MW :

16.5kDa

Aliases :

ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A