antibody

Mouse Monoclonal Antibody to CSNK2A2

30405

100μl

monoclonal

mouse

nonconjugated

1E1

The same clone is also sold as:

• Invitrogen: MA5-17062

human, mouse

western blot, ELISA, flow cytometry

Mouse Monoclonal Antibody to CSNK2A2

Human; Mouse;

1E1;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

1.Eur J Immunol. 2009 Jan;39(1):267-79. 2.Cell Mol Life Sci. 2009 Jan;66(2):339-49.

Monoclonal Antibody

41.2kDa

CK2A2; CSNK2A1; FLJ43934