antibody

Mouse Monoclonal Antibody to PAX5

30395

0.1 mg

monoclonal

mouse

nonconjugated

7D3

The same clone is also sold as:

• Invitrogen: MA5-17143

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to PAX5

Human;

7D3;

Mouse IgG1

0.1 mg

4℃; -20℃ for long term storage

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1.Cancer Res. 2011 Dec 15;71(24):7345-50. 2.Am J Clin Pathol. 2010 Jan;133(1):41-8.

Monoclonal Antibody

45kDa

BSAP