Mouse Monoclonal Antibody to VAV1 | ProMab 30390 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to VAV1

catalog :

30390

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2E1.1

The same clone is also sold as:

Invitrogen: MA5-17198

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30390

Title :

Mouse Monoclonal Antibody to VAV1

Species :

Human

Clone :

2E11;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Immunogen :

Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/250; FCM: 1/200 - 1/400

References :

1.Acta Pharmacol Sin. 2011 Jan;32(1):99-107. ; 2.Cell Tissue Res. 2011 Jul;345(1):163-75. ;

Type :

Monoclonal Antibody

MW :

98.3kDa

Aliases :

VAV