Mouse Monoclonal Antibody to E2F1 | ProMab 30384 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to E2F1

catalog :

30384

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8G9

The same clone is also sold as:

Invitrogen: MA5-17070

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30384

Title :

Mouse Monoclonal Antibody to E2F1

Species :

Human; Mouse

Clone :

8G9;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Immunogen :

Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli. ; ;

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.Cancer Res. 2010 Dec 1;70(23):9711-20. ; 2.Mol Cancer Ther. 2010 May;9(5):1265-73. ;

Type :

Monoclonal Antibody

MW :

46.9kDa

Aliases :

RBP3; E2F-1; RBAP1; RBBP3