Mouse Monoclonal Antibody to DCX | ProMab 30381 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to DCX

catalog :

30381

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

'2G5

The same clone is also sold as:

Abcam: ab135349
Abnova: MAB12993
Invitrogen: MA5-17066
Novus Biologicals: NBP2-37476

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

30381

Title :

Mouse Monoclonal Antibody to DCX

Species :

Human

Clone :

2G5;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen :

Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli. ; ;

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.FASEB J. 2009 Dec;23(12):4276-87. ; 2.J Cell Biol. 2010 Nov 1;191(3):463-70. ;

Type :

Monoclonal Antibody

MW :

49.3kDa

Aliases :

DC; DBCN; LISX; SCLH; XLIS