This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to PPM1A
catalog :
30376
quantity :
0.1 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7F12

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, flow cytometry
product information
Catalog :
30376
Title :
Mouse Monoclonal Antibody to PPM1A
Species :
Human; Monkey
Clone :
7F12;
lsotype :
Mouse IgG1
Size :
0.1 mg
Storage :
4℃; -20℃ for long term storage
Description :
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Immunogen :
Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli. ; ;
Formulation :
Purified antibody in PBS with 0.05% sodium azide
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400
References :
1.Biol Psychiatry. 2011 Feb 15;69(4):360-5. ; 2.Cell Signal. 2009 Jan;21(1):95-102. ;
Type :
Monoclonal Antibody
MW :
42.4kDa
Aliases :
PP2CA; PP2Calpha; PP2C-ALPHA
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
http://www.promab.com
1-866-339-0871
headquarters: USA