Mouse Monoclonal Antibody to MAPK8 | ProMab 30369 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MAPK8

catalog :

30369

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1-E-5

The same clone is also sold as:

OriGene: AM06773PU-N
Invitrogen: MA5-17117

reactivity :

human, mouse

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30369

Title :

Mouse Monoclonal Antibody to MAPK8

Species :

Human; Mouse

Clone :

1E5;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen :

Purified recombinant fragment of human MAPK8 expressed in E. Coli. ;

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

References :

1. Mol Biol Cell. 2011 Jan 1;22(1):117-27. ; 2. Cell Cycle. 2010 May 15;9(10):1951-9. ; ; ; ;

Type :

Monoclonal Antibody

MW :

48.3kDa

Aliases :

JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2