Mouse Monoclonal Antibody to ALPL | ProMab 30337 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ALPL

catalog :

30337

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

#2F4

The same clone is also sold as:

Abcam: ab126820
Abnova: MAB12991
Novus Biologicals: NBP2-22193
Invitrogen: MA5-17030
OriGene: AM06737PU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30337

Title :

Mouse Monoclonal Antibody to ALPL

Species :

Human

Clone :

2F4;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Immunogen :

Purified recombinant fragment of human ALPL expressed in E. Coli. ;

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

J Rheumatol. 2009 Dec;36(12):2758-65. ; Calcif Tissue Int. 2009 Sep;85(3):228-34. ;

Type :

Monoclonal Antibody

MW :

57.3kDa

Aliases :

HOPS; TNAP; APTNAP; TNSALP; AP-TNAP