Mouse Monoclonal Antibody to FAS | ProMab 30328 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to FAS

catalog :

30328

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F8D6

The same clone is also sold as:

Novus Biologicals: NBP2-13078
OriGene: AM06732PU-N

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30328

Title :

Mouse Monoclonal Antibody to FAS

Species :

human

Clone :

4F8D6;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Immunogen :

Purified recombinant fragment of human FAS expressed in E. Coli. ;

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

References :

Int J Surg Pathol. 2010 Dec;18(6):493-8 ; Am J Hum Genet. 2009 Nov;85(5):628-42 ;

Type :

Monoclonal Antibody

MW :

37.7kDa

Aliases :

APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6