This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to RAF1
catalog :
30325
quantity :
0.1 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G4

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, flow cytometry
product information
Catalog :
30325
Title :
Mouse Monoclonal Antibody to RAF1
Species :
Human
Clone :
4G4;
lsotype :
Mouse IgG1
Size :
0.1 mg
Storage :
4℃; -20℃ for long term storage
Description :
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Immunogen :
Purified recombinant fragment of human RAF1 expressed in E. Coli. ;
Formulation :
Purified antibody in PBS with 0.05% sodium azide
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
References :
1. Am J Hum Genet. 2009 Nov;85(5):628-42. ; 2. Mol Cancer Res. 2009 Oct;7(10):1635-44. ;
Type :
Monoclonal Antibody
Aliases :
NS5; CRAF; Raf-1; c-Raf
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
http://www.promab.com
1-866-339-0871
headquarters: USA