Mouse Monoclonal Antibody to PSMB8 | ProMab 30255 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PSMB8

catalog :

30255

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1.A.5

The same clone is also sold as:

Abnova: MAB10306
Invitrogen: MA5-15890
OriGene: AM06666SU-N

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog :

30255

Title :

Mouse Monoclonal Antibody to PSMB8

Species :

Human; Rat

Clone :

1A5;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Immunogen :

Purified recombinant fragment of human PSMB8 expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. Genes Chromosomes Cancer. 2009 May;48(5):410-8. ; 2. Respir Med. 2010 Jun;104(6):889-94. Epub 2010 Feb 11. ;

Type :

Monoclonal Antibody

MW :

30kDa

Aliases :

JMP; LMP7; D6S216; PSMB5i; RING10; D6S216E; MGC1491