Mouse Monoclonal Antibody to LMNA | ProMab 30247 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to LMNA

catalog :

30247

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E7

The same clone is also sold as:

Abnova: MAB10790
Invitrogen: MA5-15882
OriGene: AM06658SU-N

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

30247

Title :

Mouse Monoclonal Antibody to LMNA

Species :

Human; Mouse; Rat

Clone :

4E7;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Immunogen :

Purified recombinant fragment of human LMNA expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Muscle Nerve. 2010 Jan;41(1):85-91. ; 2. Endocrine. 2009 Dec;36(3):518-23.

Type :

Monoclonal Antibody

MW :

74kDa

Aliases :

FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1