Mouse Monoclonal Antibody to AIF | ProMab 30245 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to AIF

catalog :

30245

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E7

The same clone is also sold as:

Abnova: MAB10484
OriGene: AM06656SU-N

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

30245

Title :

Mouse Monoclonal Antibody to AIF

Species :

Human; Mouse; Monkey; Rat

Clone :

4E7;

lsotype :

Mouse IgG2b

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10

Immunogen :

Purified recombinant fragment of human AIF expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Apoptosis. 2009 Jun;14(6):796-808. ; 2. PLoS One. 2009;4(2):e4394. Epub 2009 Feb 6.

Type :

Monoclonal Antibody

MW :

67kDa

Aliases :

AIFM1; AIF; PDCD8; COXPD6; MGC111425