Mouse Monoclonal Antibody to GCK | ProMab 30243 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to GCK

catalog :

30243

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G6

The same clone is also sold as:

Invitrogen: MA5-15878
Abnova: MAB10666
OriGene: AM06654SU-N

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30243

Title :

Mouse Monoclonal Antibody to GCK

Species :

Human

Clone :

4G6;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Immunogen :

Purified recombinant fragment of human GCK expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Mol Endocrinol. 2009 Dec;23(12):1983-9. ; 2. Int J Mol Med. 2009 Aug;24(2):233-46.

Type :

Monoclonal Antibody

MW :

52kDa

Aliases :

GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3