Mouse Monoclonal Antibody to NFKB1 | ProMab 30224 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to NFKB1

catalog :

30224

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5D10

The same clone is also sold as:

OriGene: AM06636SU-N
Invitrogen: MA5-15860
Abnova: MAB10829

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30224

Title :

Mouse Monoclonal Antibody to NFKB1

Species :

Human

Clone :

5D10;

lsotype :

Mouse IgG2a

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen :

Purified recombinant fragment of human NFKB1 expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Cytokine. 2010 Feb;49(2):215-20. ; 2. Chemotherapy. 2009;55(5):381-5.

Type :

Monoclonal Antibody

MW :

50kDa/105kDa

Aliases :

p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B