antibody

Mouse Monoclonal Antibody to ATM

30173

100μl

monoclonal

mouse

nonconjugated

5-C-5

The same clone is also sold as:

• OriGene: AM06585SU-N
• Invitrogen: MA5-15816
• Abnova: MAB10495

western blot, ELISA

Mouse Monoclonal Antibody to ATM

Human

5C5;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

Purified recombinant fragment of human ATM expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. Am J Hum Genet. 2008 Aug;83(2):243-53. ; 2. Mol Cell. 2008 Jul 25;31(2):167-77.

Monoclonal Antibody

351kDa

AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; MGC74674; DKFZp781A0353; ATM