antibody

Mouse Monoclonal Antibody to CTCF

30149

100μl

monoclonal

mouse

nonconjugated

1D11

The same clone is also sold as:

• Invitrogen: MA5-15792
• Abnova: MAB10575
• OriGene: AM06561SU-N

western blot, ELISA

Mouse Monoclonal Antibody to CTCF

Human; Monkey

1D11;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

Purified recombinant fragment of human CTCF expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. J Mol Med. 2008 Sep;86(9):1057-66. ; 2. J Exp Med. 2008 Apr 14;205(4):785-98. ; 3. EMBO J. 2008 Feb 20;27(4):654-66.

Monoclonal Antibody

83kDa

CTCF