Mouse Monoclonal Antibody to SNAI1 | ProMab 30145 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to SNAI1

catalog :

30145

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D2

The same clone is also sold as:

Abnova: MAB10325
Invitrogen: MA5-15791
OriGene: AM06589SU-N

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30145

Title :

Mouse Monoclonal Antibody to SNAI1

Species :

Human

Clone :

6D2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Immunogen :

Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Exp Cell Res. 2008 Aug 1;314(13):2448-53. ; 2. Mol Cell Biol. 2008 Aug;28(15):4772-81.

Type :

Monoclonal Antibody

MW :

29kDa

Aliases :

SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1