Mouse Monoclonal Antibody to FOXD3 | ProMab 30128 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to FOXD3

catalog :

30128

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5G9

The same clone is also sold as:

OriGene: AM06554SU-N, AM06541SU-N
Invitrogen: MA5-15731
Abnova: MAB10653, MAB10652

reactivity :

human, mouse

application :

western blot, ELISA

product information

Catalog :

30128

Title :

Mouse Monoclonal Antibody to FOXD3

Species :

Human; Mouse; Monkey

Clone :

5G9;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

Immunogen :

Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Blood. 1993 Jun 1;81(11):2854-9. ; 2. Am J Hum Genet. 2001 Mar;68(3):627-41. ;

Type :

Monoclonal Antibody

MW :

48kDa

Aliases :

AIS1; HFH2; Genesis; FOXD3