Mouse Monoclonal Antibody to STAT3 | ProMab 30122 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to STAT3

catalog :

30122

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B5

The same clone is also sold as:

Bio-Rad: VMA00242
Abnova: MAB10397
Novus Biologicals: NBP1-51667
Invitrogen: MA5-15712
OriGene: AM06536SU-N

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog :

30122

Title :

Mouse Monoclonal Antibody to STAT3

Species :

Human; Mouse; Monkey

Clone :

3B5;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Immunogen :

Purified recombinant fragment of human STAT3 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. J Mol Graph Model. 2009 Nov;28(4):347-56. ; 2. Bone. 2010 Feb;46(2):524-33.

Type :

Monoclonal Antibody

MW :

88kDa

Aliases :

APRF; HIES; FLJ20882; MGC16063; STAT3