Mouse Monoclonal Antibody to CDH1 | ProMab 30121 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CDH1

catalog :

30121

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7H12

The same clone is also sold as:

Abnova: MAB10546
Novus Biologicals: NBP2-19051
OriGene: AM06535SU-N
Invitrogen: MA5-15711

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

30121

Title :

Mouse Monoclonal Antibody to CDH1

Species :

Human; Mouse; Monkey

Clone :

7H12;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

Immunogen :

Purified recombinant fragment of human CDH1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Nat Genet. 2009 Dec;41(12):1330-4. ; 2. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):515-9. ; 3. J Biol Chem. 2010 Feb 26;285(9):6658-69.

Type :

Monoclonal Antibody

MW :

135kDa

Aliases :

UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1