Mouse Monoclonal Antibody to CRTC1 | ProMab 30075 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CRTC1

catalog :

30075

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1.B.5

The same clone is also sold as:

OriGene: AM06483SU-N
Abnova: MAB10614
Invitrogen: MA5-15666

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, flow cytometry

product information

Catalog :

30075

Title :

Mouse Monoclonal Antibody to CRTC1

Species :

Human

Clone :

1B5;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Immunogen :

Purified recombinant fragment of human CRTC1 expressed in E. Coli. ; ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Genes Chromosomes Cancer. 2007 Jun;46(6):559-63. ; 2. Cancer Genet Cytogenet. 2008 Jan 15;180(2):135-9. ; 3. Biosci Rep. 2009 Apr;29(2):77-87.

Type :

Monoclonal Antibody

MW :

67kDa

Aliases :

MECT1; TORC1; WAMTP1; FLJ14027; KIAA0616; CRTC1