Mouse Monoclonal Antibody to KLHL13 | ProMab 30067 product information

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to KLHL13

catalog :

30067

quantity :

100μl

price :

308.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8D1

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

ProMab product webpage

citations: 1

Reference
Jin L, Pahuja K, Wickliffe K, Gorur A, Baumgärtel C, Schekman R, et al. Ubiquitin-dependent regulation of COPII coat size and function. Nature. 2012;482:495-500 pubmed publisher

product information

Catalog :

30067

Title :

Mouse Monoclonal Antibody to KLHL13

Species :

Human

Clone :

8D1;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

Immunogen :

Purified recombinant fragment of human KLHL13 expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. DNA Res. 2000 Feb 28;7(1):65-73. ; 2. Genome Res. 2004 Sep;14(9):1711-8. ; 3. Cell. 2009 Jul 23;138(2):389-403.

List Price (USD) :

308.00 USD

Type :

Monoclonal Antibody

MW :

74kDa

Aliases :

BKLHD2; FLJ10262; MGC74791; KLHL13

more info or order :

ProMab product webpage