Mouse Monoclonal Antibody to CCND1 | ProMab 30059 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CCND1

catalog :

30059

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D8

The same clone is also sold as:

Abnova: MAB10521
OriGene: AM06463SU-N
Invitrogen: MA5-15650

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30059

Title :

Mouse Monoclonal Antibody to CCND1

Species :

Human

Clone :

3D8;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer. Cyclin D1 has also been linked to the development and progression of several cancers including breast, bladder, esophagus, and lung.

Immunogen :

Purified recombinant fragment of human CCND1 expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. J Orthop Sci. 2009 Sep;14(5):623-30. ; 2. Mod Pathol. 2010 Feb;23(2):225-34.

Type :

Monoclonal Antibody

MW :

33.7kDa

Aliases :

BCL1; PRAD1; U21B31; D11S287E; CCND1