Mouse Monoclonal Antibody to CDKN1B | ProMab 30044 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CDKN1B

catalog :

30044

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D8

The same clone is also sold as:

OriGene: AM06442SU-N
Invitrogen: MA5-15635

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30044

Title :

Mouse Monoclonal Antibody to CDKN1B

Species :

Human

Clone :

3D8;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Immunogen :

Purified recombinant fragment of human CDKN1B expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Exp Mol Med. 2009 Nov 30;41(11):765-71. ; 2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18. ;

Type :

Monoclonal Antibody

MW :

22kDa

Aliases :

KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B