Mouse Monoclonal Antibody to BMX | ProMab 30043 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to BMX

catalog :

30043

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1-C-6

The same clone is also sold as:

Invitrogen: MA5-15634
OriGene: AM06441SU-N
Abnova: MAB10508

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30043

Title :

Mouse Monoclonal Antibody to BMX

Species :

Hunam

Clone :

1C6;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Immunogen :

Purified recombinant fragment of human BMX expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Oncogene. 2004 Mar 11;23(10):1838-44. ; 2. Nat Cell Biol. 2005 Aug;7(8):797-807. ; 3. Blood. 2008 Feb 15;111(4):1781-8.

Type :

Monoclonal Antibody

MW :

78kDa

Aliases :

ETK; PSCTK2; PSCTK3; BMX