Mouse Monoclonal Antibody to XBP1 | ProMab 30035 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to XBP1

catalog :

30035

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C4

The same clone is also sold as:

OriGene: AM06434SU-N
Invitrogen: MA5-15626

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

30035

Title :

Mouse Monoclonal Antibody to XBP1

Species :

Human

Clone :

1C4;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Immunogen :

Purified recombinant fragment of human XBP1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. J Biol Chem. 2009 May 29;284(22):14904-13. ; 2. Neoplasia. 2009 May;11(5):436-47. ; 3. Clin Cancer Res. 2009 Jun 1;15(11):3834-41.

Type :

Monoclonal Antibody

MW :

28kDa

Aliases :

XBP2; TREB5; XBP1