Mouse Monoclonal Antibody to Pirh2 | ProMab 30005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Pirh2

catalog :

30005

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H10

The same clone is also sold as:

Abnova: MAB10298
OriGene: AM06384SU-N
Invitrogen: MA5-15596

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

30005

Title :

Mouse Monoclonal Antibody to Pirh2

Species :

Human; Rat

Clone :

1H10;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.

Immunogen :

Purified recombinant fragment of human Pirh2 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Biochem Biophys Res Commun. 2007 Dec 14;364(2):344-50. ; 2. J Natl Cancer Inst. 2004 Nov 17;96(22):1718-21. ; 3. Exp Cell Res. 2006 Oct 15;312(17):3370-8. ; 4. Cell. 2003 Mar 21;112(6):779-91.

Type :

Monoclonal Antibody

MW :

30kDa; 60kDa (homodimer)

Aliases :

ARNIP; CHIMP; RNF199; RCHY1