Mouse Monoclonal Antibody to ATP2C1 | ProMab 30001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ATP2C1

catalog :

30001

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G12

The same clone is also sold as:

Novus Biologicals: NBP1-47467
Abnova: MAB10496
OriGene: AM06380SU-N
Invitrogen: MA5-15592

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

30001

Title :

Mouse Monoclonal Antibody to ATP2C1

Species :

Human; Monkey

Clone :

4G12;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Immunogen :

Purified recombinant fragment of ATP2C1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. J Invest Dermatol. 2005 Nov;125(5):933-5. ; 2. J Dermatol Sci. 2006 Aug;43(2):150-1. ; 3. Dermatology. 2007;215(4):277-83.

Type :

Monoclonal Antibody

MW :

100kDa

Aliases :

HHD; BCPM; PMR1; SPCA1