Mouse Monoclonal Antibody to AKT1 | ProMab 20434 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to AKT1

catalog :

20434

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

'3A3

The same clone is also sold as:

OriGene: AM06526SU-N
Invitrogen: MA5-15591
Novus Biologicals: NBP1-51602

reactivity :

human, mouse

application :

western blot, ELISA

product information

Catalog :

20434

Title :

Mouse Monoclonal Antibody to AKT1

Species :

Human; Mouse; Monkey

Clone :

3A3;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

Immunogen :

Purified recombinant fragment of human AKT1 expressed in E. Coli. ; ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. J Cell Physiol. 2010 Oct;225(1):168-73. ; 2. Mol Cell Biol. 1995 Apr;15(4):2304-10. ; 3. EMBO J. 1997 Sep 1;16(17):5445-54.

Type :

Monoclonal Antibody

MW :

56kDa

Aliases :

AKT; PKB; RAC; PRKBA; MGC99656; PKB-ALPHA; RAC-ALPHA; AKT1