Mouse Monoclonal Antibody to ABL2 | ProMab 20429 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ABL2

catalog :

20429

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H1

The same clone is also sold as:

Abnova: MAB15258
OriGene: AM06500SU-N
Invitrogen: MA5-15586

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

product information

Catalog :

20429

Title :

Mouse Monoclonal Antibody to ABL2

Species :

Human; Mouse

Clone :

1H1;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.

Immunogen :

Purified recombinant fragment of ABL2 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000

References :

1. Yoshimi I, Takashi I, Tsuneyuki O, et al. Blood. 2000; 95(6): 2126-2131. ; 2. Scheijen, B. and Griffin, J.D. Oncogene. 2002); 21：3314-33. ;

Type :

Monoclonal Antibody

MW :

128kDa

Aliases :

ARG; ABLL; FLJ22224; FLJ31718; FLJ41441