Mouse Monoclonal Antibody to NGFR | ProMab 20417 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to NGFR

catalog :

20417

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F1C2

The same clone is also sold as:

Invitrogen: MA5-15574
Abnova: MAB10831
OriGene: TA336800
Novus Biologicals: NBP1-51590, NBP2-80874

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, flow cytometry

product information

Catalog :

20417

Title :

Mouse Monoclonal Antibody to NGFR

Species :

Human

Clone :

2F1C2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

Immunogen :

Purified recombinant fragment of human NGFR expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. J Invest Dermatol. 1992 Dec;99(6):734-42. ; 2. Nature. 1997 Aug 7;388(6642):548-54. ; 3. Exp Neurol. 2002 Nov;178(1):104-11. ; 4. Science. 2004 May 7;304(5672):870-5.

Type :

Monoclonal Antibody

MW :

45kDa

Aliases :

CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR