Mouse Monoclonal Antibody to CD38 | ProMab 20413 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CD38

catalog :

20413

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6E12D

The same clone is also sold as:

Novus Biologicals: NBP1-47462
Invitrogen: MA5-15570
Abnova: MAB10535
OriGene: AM06390SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20413

Title :

Mouse Monoclonal Antibody to CD38

Species :

Human

Clone :

6E12D;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

Immunogen :

Purified recombinant fragment of human CD38 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Trends Biochem Sci. 1992 Dec;17(12):495. ; 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. ; 3. Exp Hematol. 2002 Jun;30(6):582-9. ; 4. Mol Immunol. 2006 Mar;43(7):1029-39. ;

Type :

Monoclonal Antibody

MW :

34kDa

Aliases :

T10; CD38