Mouse Monoclonal Antibody to CTNNB1 | ProMab 20412 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CTNNB1

catalog :

20412

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D5

The same clone is also sold as:

Invitrogen: MA5-15569
Abnova: MAB10619
OriGene: AM06389SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

20412

Title :

Mouse Monoclonal Antibody to CTNNB1

Species :

Human

Clone :

4D5;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.

Immunogen :

Purified recombinant fragment of human CTNNB1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Cancer Gennet Cytogenet. 2008. 187(1):12-8 ; 2. Hepatobiliary Pancreat Dis Int. 2008. 7(5):490-6 ; 3. J Biol Chem. 1995. 270(10):5549-55 ; 4. EMBO J. 1998. 17(5):137-84 ;

Type :

Monoclonal Antibody

MW :

85kDa

Aliases :

CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; CTNNB1