Mouse Monoclonal Antibody to ITGA5 | ProMab 20411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ITGA5

catalog :

20411

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10F6

The same clone is also sold as:

Novus Biologicals: NBP2-37666
OriGene: AM06388SU-N
Abnova: MAB10703
Invitrogen: MA5-15568

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

20411

Title :

Mouse Monoclonal Antibody to ITGA5

Species :

Human

Clone :

10F6;

lsotype :

Mouse IgG2a

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.

Immunogen :

Purified recombinant fragment of human ITGA5 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Proc Natl Acad Sci USA. 1993. 90(22):10553-7 ; 2. J Cell Biol. 1998. 143(7):2081-92 ; 3. Mol Biol Cell. 2000. 11(9):3109-21 ; 4. J Cell Biol. 2001. 152(1):65-73 ; 5. J Biol Chem. 2002. 277(22):19800-5 ;

Type :

Monoclonal Antibody

MW :

114kDa

Aliases :

FNRA; CD49e; VLA5A; ITGA5