Mouse Monoclonal Antibody to Metadherin | ProMab 20407 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Metadherin

catalog :

20407

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F11C3

The same clone is also sold as:

Abnova: MAB10817
Novus Biologicals: NBP1-51585
Cell Signaling Technology: 9596
OriGene: AM06379PU-N
Invitrogen: MA5-15564

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog :

20407

Title :

Mouse Monoclonal Antibody to Metadherin

Species :

Human

Clone :

2F11C3;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Immunogen :

Purified recombinant fragment of human Metadherin expressed in E. Coli.

Formulation :

Antibody are purified by protein G affinity chromatography. ; Liquid in PBS containing 50% glycerol and 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Cancer Cell. 2004 Apr;5(4):365-74. ; 2. Exp Cell Res. 2004 Oct 15;300(1):134-48. ; 3. Cancer Cell. 2009 Jan 6;15(1):9-20.

Type :

Monoclonal Antibody

MW :

64kDa

Aliases :

3D3; AEG1; LYRIC; MTDH