Mouse Monoclonal Antibody to PTEN | ProMab 20399 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PTEN

catalog :

20399

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B8

The same clone is also sold as:

OriGene: AM06375PU-N
Invitrogen: MA5-15560
Abnova: MAB10405

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, flow cytometry

product information

Catalog :

20399

Title :

Mouse Monoclonal Antibody to PTEN

Species :

Human; Mouse;

Clone :

1B8;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Immunogen :

Purified recombinant fragment of PTEN expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Nat Genet. 1998 Aug;19(4):348-55.; 2. Oncogene. 1999 May 20;18(20):3181-5.; 3. Eur J Immunol. 2002 Apr;32(4):1196-204.;

Type :

Monoclonal Antibody

MW :

54kDa

Aliases :

BZS; MHAM; TEP1; PTEN1