Mouse Monoclonal Antibody to PGA5 | ProMab 20396 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PGA5

catalog :

20396

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2C1

The same clone is also sold as:

Invitrogen: MA5-15558
Abnova: MAB10295
OriGene: AM06373SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20396

Title :

Mouse Monoclonal Antibody to PGA5

Species :

Human

Clone :

2C1;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Immunogen :

Purified recombinant fragment of human PGA5 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. ; 2. Nat Genet. 2004 Jan;36(1):40-5.

Type :

Monoclonal Antibody

MW :

42kDa

Aliases :

Pepsinogen 5; Pepsin A